Began his career as an employee of the Museo di Fisica e Storia Naturale of Florence, where he was the first to compile a catalogue of old scientific instruments belonging to the Lorraine institution. He was appointed director of the Museum in 1844 after its reorganization and the opening, inside the building, of the Tribuna di Galileo (1841) as a repository for the old instruments and the Galilean relics. Meucci purchased and commissioned the restoration of many instruments, particularly astronomical ones, conducting detailed studies of the Arab instruments now preserved at the Museo Galileo of Florence.